ANTI-AGEING + ENERGY…How does it work?
Taroeva was founded on the belief that placing our customer’s health, safety and wellbeing should be at the heart of everything we do. And this ethos has been our core value in the pursuit of developing bio-active nutrition that can make a difference to our lives today; it's not just about longevity, but feeling healthier as we age.
We don’t want you to just take our “word for it”, we want you to be totally informed before choosing to use our products. In this article we will explain the ins & outs of our product, how it helps you on your wellness journey, along with clinical trials and scientific studies to back all claims.
ANTI-AGEING + ENERGY
So what is our ANTI-AGEING + ENERGY blend and why is it improving the biological health of not just Australian’s, but also our customers globally?
We keep our products simple, focusing on the things that actually work. The ANTI-AGEING + ENERGY blend contains two synergetic ingredients (NMN & RSV), delivered at an optimal dose that translates into real bio-active benefits. There’s no need to complicate our product by adding multiple low dose ingredients that offer minimal nutritional and wellbeing outcomes.
Nicotinamide Mononucleotide (NMN)
NMN is considered as a key component to increase NAD+ levels within our bodies. As we age, our NAD+ levels decrease, leading to DNA breakdown, lower levels of energy, age related weight gain, amongst many other signs of ageing. Supplementing with NMN supports longevity by supporting and boosting your NAD+ levels.
Trans-Resveratrol (RSV)
RSV has anti-aging, anti-carcinogenic, anti-inflammatory, and anti-oxidant properties that are relevant to chronic diseases and longevity in humans. As a powerful antioxidant, resveratrol acts at the cellular level to boost NAD+ by increasing the activity of a key NAD+ synthesising enzyme involved in DNA protection and repair, also supporting bone health, cardiovascular health, blood glucose levels, healthy cognitive function, and skin youthfulness.
Potential Benefits :
Anti-ageing via NAD+ production
Energy production
Cardiovascular health
Brain function
Metabolic support
Supporting sleep quality & Circadian rhythm
Anti-inflammatory
Regulating blood pressure & insulin sensitivity
Pre-menopause support
What is Nicotinamide Mononucleotide (NMN)
NMN supplement is gaining popularity as an anti-ageing and energy-boosting supplement. But what exactly is NMN, and how does it work? Here we will explore the basics of NMN supplement, the science behind it, its potential health benefits and how to use it effectively.
Let's start with the basics. NMN stands for Nicotinamide Mononucleotide, a naturally occurring compound found in our bodies. It is a precursor to NAD+, which plays a vital role in energy metabolism and cellular function.
But what exactly does that mean? Well, NAD+ is a coenzyme that is crucial for various biological processes. One of its primary functions is DNA repair. Every day, our DNA is subjected to damage from various sources such as UV radiation, chemicals, and oxidative stress. Without proper repair mechanisms, these damages can accumulate and lead to mutations, which in turn can contribute to ageing and the development of diseases.
Aside from DNA repair, NAD+ also plays a critical role in cellular energy production. Our cells rely on a process called cellular respiration to generate energy in the form of adenosine triphosphate (ATP). NAD+ is a key player in this process, acting as an electron carrier in the electron transport chain, which ultimately leads to the production of ATP. Without sufficient NAD+, cellular energy production can be compromised, leading to fatigue and decreased overall energy levels.
Let’s Take a Closer Look
NMN is not just a bystander in the production of NAD+. It actively participates in the synthesis of this essential coenzyme. As we age, NAD+ levels naturally decline, which can impact overall health and energy levels. This decline is believed to be one of the contributing factors to the ageing process itself. By supplementing with NMN, we can potentially boost NAD+ levels and counteract the effects of ageing.
Research has shown that NMN supplementation can have numerous benefits. In addition to its role in DNA repair and cellular energy production, NMN has been found to improve insulin sensitivity, enhance mitochondrial function, and promote healthy ageing. It has also shown promise in protecting against age-related diseases such as neurodegenerative disorders, cardiovascular diseases, and metabolic disorders. Furthermore, NMN has been studied for its potential anti-ageing effects. Research suggests that NMN can activate certain proteins called sirtuins, which are known to play a role in longevity. By activating these sirtuins, NMN can help promote cellular health and extend lifespan.
It is important to note that while NMN shows great promise, further research is still needed to fully understand its mechanisms of action and long-term effects. Additionally, it is always advisable to consult with a healthcare professional before starting any new supplement regimen. Once ingested, NMN is absorbed in the small intestine and enters the bloodstream. From there, it is transported to various tissues, including the liver, skeletal muscles, and brain. Within these tissues, NMN undergoes a remarkable transformation. It is enzymatically converted into NR, a process that is crucial for its subsequent utilization in NAD+ synthesis. This conversion from NMN to NR is facilitated by the enzyme nicotinamide phosphoribosyltransferase (NAMPT).
Once converted into NR, this precursor molecule is efficiently taken up by cells through specific transporters. Inside the cells, NR is converted back into NMN through the action of another enzyme called nicotinamide riboside kinase (NRK). Now, with NMN back in action, it can be utilized as a substrate for the final step in NAD+ synthesis. Through a series of enzymatic reactions involving NMN adenylyltransferase (NMNAT), NMN is converted into NAD+, the coenzyme that is essential for numerous cellular processes. This intricate biological pathway ensures that NMN is effectively utilized to produce NAD+, allowing for the potential benefits associated with NMN supplementation.
In conclusion, NMN supplement, short for Nicotinamide Mononucleotide, is a compound that acts as a precursor to NAD+. NAD+ is essential for DNA repair and cellular energy production. By supplementing with NMN, we are able to boost NAD+ levels and improve overall health and energy levels.
NMN Dosage
According to the latest clinical trials with NMN supplements, the optimal and safe dose of NMN for 40-65 years old is 500 mg/day to 1000 mg/day. Most of the NMN trials with humans were conducted with these amounts and showed no side effects.
We recommend starting at 500mg per day in the morning on an empty stomach for the first 4 weeks, and then adjust if needed.
Further Reading
There are plenty of clinical studies regarding NMN and its many benefits (please check out our “About” page for further study links)
Below is a link for the most recent clinical human study to date.
Role and Potential Mechanisms of Nicotinamide Mononucleotide in Ageing (April 2024)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10917541/
What is Trans-Resveratrol (RSV)
In the past decade, the small polyphenol resveratrol has received widespread attention as either a potential therapy or as a preventive agent for numerous diseases. Studies using purified enzymes have suggested that resveratrol has anti-aging, anti-carcinogenic, anti-inflammatory, and anti-oxidant properties that might be relevant to chronic diseases and/or longevity in humans. Although the supporting research in laboratory models is quite substantial, only recently data has emerged to describe the effects of resveratrol supplementation on physiological responses in humans.
The emerging data from human clinical trials confirms what the past decade of in vitro and laboratory animal models have suggested; resveratrol has considerable potential to improve health and prevent chronic disease in humans. Resveratrol has raised attention for being an effective antioxidant and for positively affecting the cells in the body, leading to a number of health benefits. Since its discovery, researchers have published more than 12,000 scientific papers about resveratrol, and over 200 human clinical trials involving this polyphenol have been conducted to date.
We believe the evidence is sufficiently strong to conclude that a single dose of resveratrol is able to induce beneficial physiologic responses, and that either weeks or months of resveratrol supplementation produces physiologic changes that are predictive of improved health, especially in clinical populations with compromised health.
Let’s Take a Closer Look
Resveratrol is a compound that various plants make to fight off bacteria, fungi, and other microbial attackers, or to withstand drought or lack of nutrients. It has been found in red and purple grapes, blueberries, cranberries, mulberries, lingonberries, peanuts, and Resveratrol is also abundant in the roots of Japanese knotweed.
Scientific evidence suggests that it does the same for humans by working to protect the body’s cells and support healthy ageing. Published research and clinical data indicate that resveratrol supports bone health, cardiovascular health, blood glucose levels, healthy cognitive function, skin youthfulness, and oral health. As a powerful antioxidant, resveratrol acts at the cellular level to boost NAD+ by increasing the activity of a key NAD+ synthesising enzyme involved in DNA protection and repair.
Resveratrol has also been shown to penetrate cells and help rejuvenate the mitochondria, again, helping to support healthy ageing. Mitochondria are the powerhouses that create energy inside every cell in our bodies. However, as we age, the mitochondrial function slowly impairs. This leads to the decline of many systems in our body as we get older, including cardiovascular, cognitive, skin, and bone systems. Resveratrol helps reverse or slow this process.
Part of the healthy ageing benefits of resveratrol can be explained by the activation of sirtuins, including SIRT1–7, a family of deacylases that play a critical role in DNA repair, and rely on NAD+ for their function. They possess remarkable capabilities to prevent diseases and even reverse or slow down certain aspects of aging. Resveratrol activates a specific sirtuin-coding gene called SIRT1 which results in gene expression and metabolic pathway activation, both of which are excellent for your energy levels and overall health.
Resveratrol Dosage
The dosage for Resveratrol depends on the person and what it is being used for. Based on studies and clinical trials, it is thought to be safe in doses up to 1500 milligrams daily. We recommend starting at a daily does of 500 mg for the first 4 weeks and if desired, build up to a maximum daily dose of 1000 mg.
As is the case with all supplements, it is wise to start with the lowest possible effective dose and build gradually as needed.
Further Reading
With over 10 years of clinical studies behind the benefits of Resveratrol, there’s an abundance of information to read. Much of the recent studies have now been focused on the benefits of Resveratrol supplementation regarding the management of cognitive decline and Alzheimer's. (please check out our “About” page for further study links)
Below is a link for a clinical human study that encompasses many of the health benefits.
Health Effects of Resveratrol: Results from Human Intervention Trials
