Resveratrol, more than a Powerful Antioxidant

In the past decade, the small polyphenol resveratrol has received widespread attention as either a potential therapy or as a preventive agent for numerous diseases. Studies using purified enzymes have suggested that resveratrol has anti-aging, anti-carcinogenic, anti-inflammatory, and anti-oxidant properties that might be relevant to chronic diseases and/or longevity in humans. Although the supporting research in laboratory models is quite substantial, only recently data has emerged to describe the effects of resveratrol supplementation on physiological responses in humans.

The emerging data from human clinical trials confirms what the past decade of in vitro and laboratory animal models have suggested; resveratrol has considerable potential to improve health and prevent chronic disease in humans. Resveratrol has raised attention for being an effective antioxidant and for positively affecting the cells in the body, leading to a number of health benefits. Since its discovery, researchers have published more than 12,000 scientific papers about resveratrol, and over 200 human clinical trials involving this polyphenol have been conducted to date.

We believe the evidence is sufficiently strong to conclude that a single dose of resveratrol is able to induce beneficial physiologic responses, and that either weeks or months of resveratrol supplementation produces physiologic changes that are predictive of improved health, especially in clinical populations with compromised health.

Let’s Take a Closer Look

Resveratrol is a compound that various plants make to fight off bacteria, fungi, and other microbial attackers, or to withstand drought or lack of nutrients. It has been found in red and purple grapes, blueberries, cranberries, mulberries, lingonberries, peanuts, and Resveratrol is also abundant in the roots of Japanese knotweed.

Scientific evidence suggests that it does the same for humans by working to protect the body’s cells and support healthy ageing. Published research and clinical data indicate that resveratrol supports bone health, cardiovascular health, blood glucose levels, healthy cognitive function, skin youthfulness, and oral health. As a powerful antioxidant, resveratrol acts at the cellular level to boost NAD+ by increasing the activity of a key NAD+ synthesising enzyme involved in DNA protection and repair.

Resveratrol has also been shown to penetrate cells and help rejuvenate the mitochondria, again, helping to support healthy ageing. Mitochondria are the powerhouses that create energy inside every cell in our bodies. However, as we age, the mitochondrial function slowly impairs. This leads to the decline of many systems in our body as we get older, including cardiovascular, cognitive, skin, and bone systems. Resveratrol helps reverse or slow this process.

Part of the healthy ageing benefits of resveratrol can be explained by the activation of sirtuins, including SIRT1–7, a family of deacylases that play a critical role in DNA repair, and rely on NAD+ for their function. They possess remarkable capabilities to prevent diseases and even reverse or slow down certain aspects of aging. Resveratrol activates a specific sirtuin-coding gene called SIRT1 which results in gene expression and metabolic pathway activation, both of which are excellent for your energy levels and overall health.

Want to find out more?, click of these links to view the scientific & research studies

https://pubmed.ncbi.nlm.nih.gov/26610561/

https://pubmed.ncbi.nlm.nih.gov/30741437/

https://pubmed.ncbi.nlm.nih.gov/30513922/

https://pubmed.ncbi.nlm.nih.gov/32900519/

https://pubmed.ncbi.nlm.nih.gov/28989978/

Resvertrol and Anti-ageing

The compound’s ability to extend lifespan in different organisms has become a major area of research.

There’s evidence that resveratrol activates certain genes that ward off the diseases of aging. It works to achieve this in the same way as calorie restriction, which has shown promise in lengthening lifespans by changing how genes express themselves.

Calorie restriction extends lifespan by increasing the activity of SIR2, a member of the conserved sirtuin family of NAD(+)-dependent protein deacetylases. Included in this family are SIR-2.1, a Caenorhabditis elegans enzyme that regulates lifespan, and SIRT1, a human deacetylase that promotes cell survival.

https://pubmed.ncbi.nlm.nih.gov/23624181/

https://pubmed.ncbi.nlm.nih.gov/15254550/

Resveratrol and Blood Pressure

Because of its antioxidant properties, Resveratrol could be a promising supplement for lowering blood pressure.

A 2015 review concluded that supplementation helped reduce the pressure exerted on artery walls when the heart beats. That type of pressure is called systolic blood pressure, and appears as the upper number in blood pressure readings.

Systolic blood pressure typically goes up with age, as arteries stiffen. When high, it’s a risk factor for heart disease. Resveratrol accomplishes this blood-pressure-lowering effect by helping to produce more nitric oxide, which causes blood vessels to relax.

https://pubmed.ncbi.nlm.nih.gov/27144581/

Resveratrol Insulin Sensitivity

Resveratrol has been shown to have several benefits for diabetes These benefits include increasing insulin sensitivity and preventing complications from diabetes.

One explanation for how Resveratrol works is that it may stop a certain enzyme from turning glucose into sorbitol, a sugar alcohol. When too much sorbitol builds up in people with diabetes, it can create cell-damaging oxidative stress.

Resveratrol with its antioxidant action may help protect against oxidative stress, which causes some of the complications of diabetes. Along with helping to decrease inflammation, Resveratrol is thought to lessen inflammation, a key contributor to chronic diseases, including diabetes and insulin sensitivity. Resveratrol also activates AMPK, a protein that helps the body metabolize glucose, assisting with lower blood sugar levels.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160010/

https://pubmed.ncbi.nlm.nih.gov/32058210/

Resveratrol and Joint Pain

Resveratrol may help relieve joint pain by preventing cartilage from breaking down

Arthritis is a common affliction that leads to joint pain and loss of mobility. Over recent years, a number of Plant-based supplements are being studied as a way to treat and prevent joint pain. When taken as a supplement, Resveratrol may help protect cartilage from deteriorating. Cartilage breakdown can cause joint pain and is one of the main symptoms of arthritis.

Research has suggested that the compound has potential to reduce inflammation and prevent damage to joints.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3344210/

Resveratrol and Brain Health

Several studies have suggested that supplementation of Resveratrol can help slow down age-related cognitive decline.

It has been studied and found to interfere with protein fragments called beta-amyloids, which are crucial to forming the plaques that are a hallmark of Alzheimer’s disease and mental decline. Additionally, Resveratrol may set off a chain of events that protects brain cells from damage, this is due to the antioxidant and anti-inflammatory activity of Resveratrol.

https://pubmed.ncbi.nlm.nih.gov/25851110/

Resveratrol Dosage

The dosage for Resveratrol depends on the person and what it is being used for, so check with your doctor. It is thought to be safe in doses up to 1500 milligrams daily. We recommend starting at a daily does of 500 mg for the first 4 weeks and if desired, build up to a maximum daily dose of 1000 mg.

As is the case with all supplements, it is wise to start with the lowest possible effective dose and build gradually as needed.

Are there side effects of Resveratrol supplementation?

No major risks have been revealed in studies that have used Resveratrol supplements at recommended dosages in healthy people.

In saying this, since high doses have been shown to stop blood from clotting in test tubes, it’s possible it could increase bleeding or bruising when taken with anti-clotting drugs, such as heparin or warfarin and may interfere with certain blood pressure medications. Doses exceeding 2500 mg may cause stomach problems such as nausea, vomiting and diarrhea

If you currently use medications, then we recommend that you check with a doctor before trying Resveratrol